Sinequan (Doxepin Hydrochloride)

Sinequan Review

Sinequan is used to treat depression, obsessive- compulsive disorders, and bed-wetting in children over 6 years of age (enuresis).

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Sinequan Drug Class and Mechanism

The mechanism of action of SINEQUAN (doxepin HCl) is not definitely known. It is not a central nervous system stimulant nor a monoamine oxidase inhibitor. The current hypothesis is that the clinical effects are due, at least in part, to influences on the adrenergic activity at the synapses so that deactivation of norepinephrine by reuptake into the nerve terminals is prevented. Animal studies suggest that doxepin HCl does not appreciably antagonize the antihypertensive action of guanethidine. In animal studies anticholinergic, antiserotonin and antihistamine effects on smooth muscle have been demonstrated. At higher than usual clinical doses, norepinephrine response was potentiated in animals. This effect was not demonstrated in humans.

Sinequan Uses

Use this as prescribed. Try to use each dose at the same time(s) each day so you remember to routinely use it. It may take 2 to 3 weeks before the full benefit of this medication becomes apparent. Do not stop using Sinequan without your doctor's approval. Nausea, headache or fatigue can occur if the drug is suddenly stopped.

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Sinequan Side Effects

Central Nervous System : fatigue, dizziness, drowsiness, lightheadedness, confusion, nightmares, agitation, increased anxiety, insomnia, seizures (infrequently), delirium, rarely induction of hypomania and schizophrenia (stop medication immediately), extrapyramidal side-effects (rarely), abuse in patients with polytoxikomania (rarely) Anticholinergic : dry mouth, obstipation, even ileus (rarely), difficulties in urinating, sweating, precepitation of glaucoma Antiadrenergic : hypotension, postural collapse (if patient arises too fast from lying/sitting position to standing), arrhythmias (sinus-tachycardia, bradycardia, av-blockade) Allergic/toxic : skin rash, photosensitivity, liver damage of the cholostatic type (rarely), hepatitis (extremely rare), leuko- or thrombopenia (rarely), agranulocytosis (very rarely), hypoplastic anemia (rarely) Others : frequently increased appetite, massive weight gain, rarely nausea, frequently impaired sexual function in men (impotence, ejaculation-difficulties), rarely hypertension, rarely polyneuropathy, in both sexes breast-enlargement and galactorrhea

Sinequan Pregnancy

If Doxepin is used chronically during pregnancy, the newborn may show a withdrawal syndrome with agitation, impaired cardio-respiratory functions, disturbed urination and defecation. Caution should be exerted in treating pregnant women on a regular basis. Doxepin is found in significant amounts in the milk of lactating women. If therapy is necessary, breastfeeding should be interrupted during treatment. In order to maintain supply, the mother may pump and discard the milk during her treatment.

Sinequan Overdose

If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include agitation, confusion, hallucinations, fever, irregular movement of the eyes, seizures, change in amount of urine, dry mouth or nose, constipation, large pupils, drowsiness, slow or shallow breathing, dizziness, unconsciousness, unusually fast or slow heartbeat, or flushing...

Sinequan More Information

Read the Medication Guide that comes with you or your family member's antidepressant medicine. This Medication Guide is only about the risk of suicidal thoughts and actions with antidepressant medicines. Talk to your, or your family member's, healthcare provider about: all risks and benefits of treatment with antidepressant medicines all treatment choices for depression or other serious mental illness